What is PSA (PSA)?
PSA is a protein produced by both cancerous and noncancerous tissue in the prostate, a small gland that sits below the bladder in males. PSA is mostly found in semen, which also is produced in the prostate.
What does it mean when your PSA level is elevated?
Elevated PSA (Prostate-Specific Antigen) Level Menu. Prostate-specific antigen (PSA) is a protein produced by the prostate gland. Blood levels of PSA can be elevated in men with prostate cancer. For this reason, measurement of PSA in the blood has been used as a screening test for prostate cancer.
What are the results of the PSA test?
The results are usually reported as nanograms of PSA per milliliter (ng/mL) of blood. The blood level of PSA is often elevated in people with prostate cancer, and the PSA test was originally approved by the FDA in 1986 to monitor the progression of prostate cancer in men who had already been diagnosed with the disease.
What is PSA traveling alone?
PSA traveling alone is called free PSA. The free-PSA test measures the percentage of unbound PSA; the PSA test measures the total of both free and bound PSA. Prostate cancer can raise PSA levels, but so can other conditions. These include an enlarged prostate, prostatitis, and advancing age.
PSA is a member of the kallikrein -related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus,…
What is the origin of P30 protein?
In 1978, Sensabaugh identified semen-specific protein p30, but proved that it was similar to E1 protein, and that prostate was the source. In 1979, Wang purified a tissue-specific antigen from the prostate (‘prostate antigen’).
What are the methods for the detection of PSA?
Methods for the detection of PSA include Ouchterlony double diffusion, crossover electrophoresis, roc … Prostate specific antigen (PSA, also known as p30), a glycoprotein produced by the prostatic gland and secreted into seminal plasma, is a marker used for demonstrating the presence of seminal fluid.
What does PSA membrane test stand for?
Midwestern Association of Forensic Scientists. Archived from the original (PDF) on 27 August 2005. Retrieved 11 May 2008. ^ Hochmeister MN, Budowle B, Rudin O, Gehrig C, Borer U, Thali M, et al. (September 1999). “Evaluation of prostate-specific antigen (PSA) membrane test assays for the forensic identification of seminal fluid”.